姓名：汉丽萍

性别：女

出生年月：1966年6月

职称/职务：副教授

学位：博士

电子邮箱：hanliping1966@163.com

办公电话：86168749

专业：细胞生物学

研究方向：细胞分子生物学

主讲课程：生物化学、分子生物学

教育经历：

1989年6月于山东大学生物系获得理学学士学位

1999年6月于东北师范大学2138cn太阳集团古天乐(中国)官方网站获得理学硕士学位

2006年12月于东北师范大学细胞与遗传研究所获得理学博士学位

科研成果：

主持项目：

1、国家自然科学基金，31050015，红系血红素合成酶ALAS2基因增强子调控基因转录机制的研究，2011.01-2012.12，20万

2、教育部留学回国科研启动基金，丁酸钠诱导红系血红素合成酶基因ALAS2表达的表观遗传调控机制研究，2011，3万

3、国家自然科学基金，31371313，BRG1在DNA双链断裂修复中的作用和机制研究，2014.01 - 2017.12，72万

专著：

1.参编：汉丽萍，《分子生物学实验指导》，出版社：高等教育出版社

2.参编：汉丽萍，《花生遗传改良》，出版社：上海科学技术出版社

学术论文：

1.Wenjing Qi, Hongyu Chen, Ting Xiao, Ruoxi Wang, Ting Li,Liping Han and Xianlu Zeng. Acetyltransferase p300 collaborates withchromodomain helicase DNA-binding protein 4(CHD4) to facilitate DNA double-strand break repair［J］

2.Xiujuan Tian, Wenjing Qi, Hongyu Chen, Xianlu Zeng, Liping Han & DonghuiMi. β-Actin regulates interleukin 6-induced p21transcription by interacting with the Rpb5 andRpb7 subunits of RNA polymerase II［J］. Animal Cells and Systems,2016,20(5): 282-288.

3.Enkhzaya Batnasan, Ruoxi Wang, Jitao Wen, Yueshuang Ke, Xiaoxue Li ,Ameer Ali Bohio, Xianlu Zeng, Hongliang Huo, Liping Han, Istvan Boldogh,Xueqing Ba.17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha［J］.Toxicology Letters，2015,232(1): 1-9.

4.Wenjing Qi, Ruoxi Wang, Hongyu Chen,Xiaolin Wang, Ting Xiao, Istvan Boldogh,Xueqing Ba, Liping Han, and Xianlu Zeng.BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51［J］.J Cell Sci ,2015,128:317-330.

5.Liping Han , Xiuzhen Ni , Lihong Gao , Yajun Fan , Jingang Mo，Sodium butyrate upregulated expression of CYP1A1 and 1B1 genes in human leukemia K562 cells［J］.China Journal of Modern Medicine，2013,21:1-7.

6.Xi Shi, Baoqing Tian, Lingxia Liu, Yanyan Gao, Chi Ma, Namusamba Mwichie, Wenlong Ma, Liping Han, Baiqu Huang, Jun Lu, Yu Zhang. Rb protein is essential to the senescence-associated heterochromatic foci formation induced by HMGA2 in primary WI38 cells［J］.J Genet Genomics. 2013,40(8):391-398.

7.Yu Zhang, Yanyan Gao, Li Zhao, Liping Han, Yang Lu, Pingfu Hou, Xi Shi, Xin Liu, Baoqing Tian, Xiuli Wang, Baiqu Huang, Jun Lu. Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells［J］.FEBS J. 2013,280(18):4625-4639.

8.Jianchao Zhang, Yang Lei, Xiaoge Gao, Qian Liang, Lili Li, Jingxin Feng, Pingfu Hou, Liping Han, Yu Zhang, Baiqu Huang, Jun Lu. p53 Attenuates the oncogenic Ras-induced epithelial-mesenchymal transition in human mammary epithelial cells［J］. Biochem Biophys Res Commun, 2013 ,434(3):606-613.

9.Liping Han, Yun Zhong, Binlu Huang, Limei Han, Lina Pan, Xin Xu , Xiuli Wang, Baiqu Huang, Jun Lu. Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promoter［J］. Blood Cells, Molecules, and Diseases, 2008，41：148-153.

10.Xiuli Wang, Lina Pan, Yunpeng Feng, Yanle Wang, Qiuju Han, Liping Han, Songyan Han, Jianhua Guo, Jun Lu, Baiqu Huang. p300 plays a role in p16INK4a expression and cell cycle arrest［J］. Oncogene, 2008, 27(13):1894-1904.

11.Songyan Han, Jun Lu, Yu Zhang, Cao Cheng, Lin Li, Liping Han, Baiqu Huang. HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter［J］. Immunology Letters, 2007, 108(2):143-150.

12.Lina Pan, Jun Lu, Xiuli Wang, Liping Han, Yu Zhang, Songyan Han, Baiqu Huang. The HDAC inhibitor TSA potentiates the doxorubicin-induced apoptosis by upregulating PTEN expression［J］. Cancer, 2007, 109(8):1676-1688.

13.Liping Han, Jun Lu, Lina Pan, Xiuli Wang, Yangguang Shao, Songyan Han, Baiqu Huang. Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene［J］. Biochem Biophys Res Commun, 2006, 348: 799-806.

14.Songyan Han, Jun Lu, Yu Zhang, Cao Cheng, Liping Han, Xiuli Wang, Lin Li, Chunyan Liu , Baiqu Huang. Recruitment of histone deacetylase 4 by transcription factors represses Interleukin-5 transcription［J］. Biochemical Journal, 2006, 400(3):439-448.

获奖情况：

1.2008；草苁蓉多糖结构与抗衰老活性(主研人);吉林省科技厅科研成果；三等奖

2.2009；Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promote（第一作者）；吉林省第七届自然科学学术成果；三等奖